The goals of this multidisciplinary research center are catalyze innovative research, stimulate educational activities, foster collaboration among basic and clinical scientists, and increase national recognition for the University in the field of research on environmental disease. The primary objective of the Center is to conduct research on the mechanisms by which environmental factors cause or influence human disease and development for methods for early detection, prevention, and control of environmentally-related diseases. This university-wide, interdisciplinary center is build on existing strengths at UK to create a nationally-recognizable program that expands research and promotes educational activities. The proposed center focuses foster basic and translational research collaborations, expand training opportunities for graduate and professional students, provide an intellectual environment for new programmatic grants, enhance faculty recruitment, and give research on environmental disease at UK an identity for national recognition.